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內(nèi)容簡介

　　當(dāng)調(diào)控珠蛋白鏈的基因發(fā)生突變、缺失、插入時(shí)，就會產(chǎn)生異常珠蛋白鏈，由異常珠蛋白鏈所合成的血紅蛋白就被稱為異常血紅蛋白。這些異常血紅蛋白在結(jié)構(gòu)、功能、壽命上與正常的血紅蛋白存在一定的差異，異常血紅蛋白也可以合并地中海貧血，引起了明顯的臨床癥狀。目前國內(nèi)已廣泛采用毛細(xì)管電泳法篩查血紅蛋白病，并通過基因測序方法確認(rèn)異常血紅蛋白。本書的主要內(nèi)容可以分為如下兩大方面：一、概述：介紹血紅蛋白的定義，分子和蛋白結(jié)構(gòu)、各種血紅蛋白的功能和不同時(shí)期的表達(dá)濃度、檢測方法和注意事項(xiàng)；二、案例和圖譜：每種異常血紅蛋白案例的基本信息、毛細(xì)管電泳圖譜（遷移或出峰時(shí)間、峰面積），相關(guān)紅細(xì)胞的檢測數(shù)據(jù)、測序圖譜和數(shù)據(jù)庫資料。

作者簡介

　　醫(yī)學(xué)博士，主任技師，檢驗(yàn)醫(yī)師，碩士生導(dǎo)師。任北京大學(xué)深圳醫(yī)院檢驗(yàn)科主任，1992年畢業(yè)于華中科技大學(xué)同濟(jì)醫(yī)學(xué)院，2001年獲瑞士蘇黎世大學(xué)醫(yī)學(xué)博士學(xué)位。中國老年病學(xué)會檢驗(yàn)分會常務(wù)委員，廣東省醫(yī)學(xué)會檢驗(yàn)分會常務(wù)委員，廣東省醫(yī)師協(xié)會檢驗(yàn)醫(yī)師分會常委，廣東省中西醫(yī)結(jié)合學(xué)會檢驗(yàn)分會副主委，廣東省醫(yī)院管理協(xié)會臨床實(shí)驗(yàn)室管理分會副主委，深圳市醫(yī)學(xué)會檢驗(yàn)分會主任委員，深圳市醫(yī)師協(xié)會檢驗(yàn)醫(yī)師分會副會長。

圖書目錄

第一章異常血紅蛋白概述
1. 異常血紅蛋白的遺傳基礎(chǔ)/ 002
2. 異常血紅蛋白的功能改變/ 004
3. 異常血紅蛋白命名/ 004
4. 異常血紅蛋白流行情況/ 004
5. 異常血紅蛋白常用篩查檢測技術(shù)/ 005
第二章HBA 異常血紅蛋白
1. Hb J-Toronto/ 012
2. Hb Galliera Ⅱ/ 014
3. Hb Park Ridge/ 018
4. Hb J-Wenchang-Wuming/ 020
5. Hb Albany-Suma/ 022
6. Hb J-Paris-Ⅰ/ 024
7. Hb Ottawa/ 026
8. Hb I-Interlaken/ 028
9. Hb Liaoning/ 030
10. Hb Heilongjiang/ 034
11. Hb I/ 038
12. Hb Beijing/ 040
13. Hb Handsworth/ 042
14. Hb J-Tashikuergan/044
15. Hb Brugg/046
16. Hb Venetia/ 050
17. Hb Chad/ 051
18. Hb Shenyang/ 054
19. Hb Hekinan Ⅱ/ 056
20. Hb Agrinio/ 058
21. Hb G-Honolulu/ 059
22. Hb O-Padova/ 064
23. Hb Queens/ 065
24. Hb Wiangpapao/ 068
25. Hb Arya/ 072
26. Hb Montgomery/ 074
27. Hb Savaria/ 076
28. Hb Hunan/ 078
29. Hb Dongguan/ 082
30. Hb Shaare Zedek/ 086
31. Hb Zurich-Albisrieden/ 090
32. Hb Liuzhou/ 091
33. Hb Zambia/ 095
34. Hb G-Waimanalo/ 099
35. Hb Sichuan/ 102
36. Hb Ube-2/ 106
37. Hb G-Philadelphia/110
38. Hb Fuchu-Ⅰ/112
39. Hb Q-Thailand/114
40. Hb Liangqing/ 125
41. Hb Matsue-Oki/ 126
42. Hb Stanleyville-Ⅱ/ 128
43. Hb Mantes-La-Jolie/ 129
44. Hb J-Singapore/ 130
45. Hb Etobicoke/131
46. Hb Wroclaw/ 135
47. Hb Luocheng/ 136
48. Hb Port Phillip/ 137
49. Hb Roanne/141
50. Hb G-Georgia/ 144
51. Hb Beziers/ 147
52. Hb Manitoba Ⅰ/ 150
53. Hb Iberia/ 153
54. Hb Strumica/154
55. Hb Broomhill/ 156
56. Hb Melusine/ 160
57. Hb Hubei/163
58. Hb O-Indonesia/167
59. Hb Phnom Penh/ 168
60. Hb Cervantes/ 172
61. Hb Groene Hart/ 173
62. Hb Owari/174
63. Hb Daxin/ 176
64. Hb Huadu/ 177
65. Hb Shantou/ 178
66. Hb Questembert/ 182
67. Hb Val de Marne/ 183
68. Hb Jilin/ 184
69. Hb Tokoname/ 188
70. Hb Ethiopia/ 189
第三章HBB 異常血紅蛋白
1. Hb South Florida/ 194
2. Hb Raleigh/ 196
3. Hb Deer Lodge/200
4. Hb Graz/ 204
5. Hb Marseille/208
6. Hb Okayama/212
7. Hb Jiangnan/ 214
8. Hb Gorwihl/215
9. Hb C/ 216
10. Hb G-Makassar/ 218
11. Hb Lavagna/220
12. Hb S/222
13. Hb Xinyi/224
14. Hb G-Siriraj/225
15. Hb G-San Jose/ 228
16. Hb N-Timone/ 230
17. Hb P rto Alegre/ 232
18. Hb Hengyang/234
19. Hb Hamilton/238
20. Hb D-Ouled Rabah/ 239
21. Hb Cocody/242
22. Hb E-Saskatoon/244
23. Hb G-Coushatta/248
24. Hb G-Taipei/252
25. Hb Miyashiro/ 258
26. Hb E/259
27. Hb Knossos/ 269
28. Hb Fulwood/ 270
29. Hb Howick/271
30. Hb La Coruna/ 274
31. Hb San Bruno/ 278
32. Hb Athens-GA/282
33. Hb Taipei-Tien/283
34. Hb Hornchurch/286
35. Hb Haringey/ 287
36. Hb Mississippi/289
37. Hb Cenxi/292
38. Hb G-Copenhagen/293
39. Hb Maputo/295
40. Hb Gavello/296
41. Hb Yunnan/ 300
42. Hb Zurich-Langstrasse/303
43. Hb North Manchester/ 304
44. Hb Matera/ 308
45. Hb J-Bangkok/309
46. Hb Viseu/ 312
47. Hb Dahua/ 314
48. Hb J-Kaohsiung/ 315
49. Hb J-Lome/ 318
50. Hb Hikari/ 320
51. Hb Hachioji/ 322
52. Hb Hezhou/ 323
53. Hb Guangxi/326
54. Hb J-Sicilia/ 330
55. Hb M-Milwaukee-Ⅰ/333
56. Hb Loves Park/ 336
57. Hb Rambam/ 340
58. Hb J-Iran/ 342
59. Hb Penang/ 344
60. Hb Yaizu/ 345
61. Hb Taradale/ 347
62. Hb Ta-Li/ 351
63. Hb Pyrgos/ 354
64. Hb Henan/ 356
65. Hb Shenzhen/ 357
66. Hb Fort Dodge/360
67. Hb Bunbury/ 364
68. Hb Rush/ 367
69. Hb Shizuoka/368
70. Hb New York/ 372
71. Hb Zengcheng/378
72. Hb D-Los Angeles/379
73. Hb O-Arab/ 381
74. Hb Ty Gard/ 382
75. Hb Molfetta/ 386
76. Hb J-Taichung/ 390
77. Hb Nevers/392
78. Hb Camden/ 393
79. Hb Takasago/ 396
80. Hb Petit Bourg/ 398
81. Hb Hope/402
82. Hb Hinsdale/ 405
83. Hb Inglewood/ 408
第四章HBD 異常血紅蛋白
1. Hb A2-NYU/ 412
2. Hb A2-Dongguan/414
3. Hb A2-Sanremo/416
4. Hb A2-Qiaokou/418
5. Hb A2-Melbourne/420
6. Hb A2-Guangdong/422
7. Hb A2-Yunnan/424
8. Hb A2-Henan/426
9. Hb A2-Kiriwong/428
10. Hb A2-Wuchang/ 430
11. Hb A2-Sichuan/432
12. Hb A2-Tianhe/434
13. Hb A2-Troodos/ 435
14. HBD ：c.349C>G/437
15. Hb A2-Coburg/439
16. Hb A2-Lepore/ 441
17. Hb A2-Liangcheng/443
18. Hb A2-Fengshun/445
19. Hb A2-Babinga/ 446
20. Hb A2-Fitzroy/448
參考文獻(xiàn)/450
附錄一異常血紅蛋白索引/452
附錄二不同珠蛋白鏈的氨基酸序列/456
附錄三英文注釋/462